发明名称 |
Alpha-substitution of unprotected beta-amino ester compounds |
摘要 |
Methods for stereoselective substitution in which a (mono or un)-alpha-substituted unprotected beta-amino ester compound or salt thereof is reacted with an aliphatic electrophile in the presence of a base selected from alkyl lithium compounds, lithium hydride, lithium amide, lithium dialkyl amides and alkali hexamethyldisilylamines.
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申请公布号 |
US6433209(B1) |
申请公布日期 |
2002.08.13 |
申请号 |
US20000491548 |
申请日期 |
2000.01.26 |
申请人 |
AVENTIS PHARMACEUTICALS INC. |
发明人 |
CHANDRAMOULI SITHAMALLI V.;O'BRIEN MICHAEL K.;POWNER TORY H. |
分类号 |
C07C227/16;C07B53/00;C07B61/00;C07C227/32;C07C229/30;C07C253/00;C07C253/30;C07C255/57;C07C255/58;(IPC1-7):C07U255/00 |
主分类号 |
C07C227/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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