发明名称 N-(ARYLOXYALKYL)HETEROARYL-8-AZABICYCLO[3.2.1]OCTANES, INTERMEDIATES AND A PROCESS FOR THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS
摘要 This invention relates to compounds of the formula (See formula I) where X is -O-, -S- or -NH-: Y is hydrogen, halogen and loweralkoxy; p is 1 or 2: n is 2, 3 or 4; R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifluoromethoxy, cyano, trifluoromethyl,(See formula II)alkyl or (See formu la III)aryl where aryl is (See formula IV); R1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifluoromethyl; m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds and compositions of this invention are useful as antipsychotic agents and as inhibitors of the reuptake of serotonin.
申请公布号 CA2060573(C) 申请公布日期 2002.08.13
申请号 CA19922060573 申请日期 1992.02.03
申请人 HOECHST-ROUSSEL PHARMACEUTICALS INC. 发明人 GLAMKOWSKI, EDWARD J.;FINK, DAVID M.;KURYS, BARBARA E.
分类号 A61K31/46;A61P25/18;A61P25/24;A61P25/26;C07D231/56;C07D261/20;C07D275/04;C07D451/02;(IPC1-7):C07D451/02 主分类号 A61K31/46
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