发明名称 |
Anthracycline analogues bearing latent alkylating substituents |
摘要 |
Compound having the structurewhere anthracycline, N, Ra, X, Rb, n and m are as defined in the specification. The compound of the invention is activatable in vivo by esterases and spontaneous dehydration to form an aldehyde. The aldehyde may couple to nucleophiles of intracellular macromolecules. The compounds of the invention are cytotoxically effective in the inhibition of human myeloma cells.
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申请公布号 |
US6433150(B2) |
申请公布日期 |
2002.08.13 |
申请号 |
US20010796606 |
申请日期 |
2001.03.02 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
FARQUHAR DAVID;CHERIF ABDALLAH |
分类号 |
A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P31/04;A61P35/00;C07H15/252;(IPC1-7):C07H15/24 |
主分类号 |
A61K31/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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