ACTIVE COMPOSITION FOR INHIBITING FATTY ACID SYNTHESIS FROM PIPER LONGUM

摘要

PURPOSE: An active composition showing a specific inhibiting activity against Lepr¬(db)/Lepr¬(db) as a model animal causing obesity by the abnormality of a leptin receptor, obtained from a Piper Longum extract is provided which has an excellent effect on inhibiting fatty acid synthesis, preventing and treating obesity, reducing blood sugar and inhibiting fatty liver. CONSTITUTION: Piper Longum is ground and extracted as much as 3 to 10 times to an alcohol aqueous solution 3 times, a concentrate is suspended in as much as 50 to 100 times by volume of distilled water, passed through diionic HP-20 resin, and a nonactive fraction is eluted with 30% methanol. The absorbed active fraction is eluted 10 to 20 times with acetone and concentrated to give an extract, which is suspended in 10 to 100 times with distilled water and extracted with chloroform and ethyl acetate to give an extract, which is suspended in 1 to 2 times with distilled water.