发明名称 |
Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
摘要 |
The present invention makes availables assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein comprising contacting a cell sensitive to the hedgehog protein with a steroidal alkaloid, or other small molecule, in a sufficient amount to reduce the sensitivity of the cell to the hedgehog protein.
|
申请公布号 |
US6432970(B2) |
申请公布日期 |
2002.08.13 |
申请号 |
US19980090622 |
申请日期 |
1998.06.04 |
申请人 |
JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE |
发明人 |
BEACHY PHILIP A.;COOPER MICHAEL K.;PORTER JEFFREY A. |
分类号 |
A61K31/00;A61K31/4355;A61K31/58;(IPC1-7):A61K31/44 |
主分类号 |
A61K31/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|