发明名称 |
Compositions and methods for inducing gene expression |
摘要 |
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of transcriptional activation. The present invention also provides recombinant viral and non-viral vectors that are able to infect and/or transfect and sustain expression of a biologically active chimeric transactivator proteins in mammalian cells. Also provided are host cell lines and non-human transgenic animals capable of expressing biologically active chimeric transactivator proteins. In another aspect, compositions and methods for treating or preventing ischemic damage associated with hypoxia-related disorders are provided.
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申请公布号 |
US6432927(B1) |
申请公布日期 |
2002.08.13 |
申请号 |
US20000579897 |
申请日期 |
2000.05.26 |
申请人 |
GENZYME CORPORATION |
发明人 |
GREGORY RICHARD J.;VINCENT KAREN |
分类号 |
C12N15/09;A61K31/711;A61K35/76;A61K38/00;A61K48/00;A61P9/10;C07K14/47;C07K14/52;C07K19/00;C12N5/10;C12N15/12;C12Q1/02;(IPC1-7):A61K31/70;C12N15/63;C12N15/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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地址 |
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