| 摘要 |
<p>A mixed liposome pharmaceutical formulation with multilamellar vesicles, which formulation may be administered through the oral or nasal membranes, or by pulmonary access. The formulation includes a proteinic pharmaceutical agent, water, an alkali metal C8 to C22 alkyl sulphate in a concentration of from 1 to 10 wt. wt.%, at least one membrane mimetic amphiphile and at least one phospholipid. The amount of each membrane mimetic amphiphile and phospholipid is present in a concentration of from 1 to 10 wt. wt.% of the total formulation, and the total concentration of membrane mimetic amphiphiles and phospholipids is less than 50 wt. wt.% of the formulation. A process for making the formulation, a container housing the formulation, and a method of administering the formulation are also disclosed. The method of administration includes mixing the formulation with a propellant and administering the mixture orally using a metered dose dispenser.</p> |
