| 摘要 |
This invention refers to the new compounds of a general formula wherein R1 is hydrogen R2 is trifluoromethyl or lower alkyl R3 is hydrogen or amino, or R1 and R2 or R3 and R2 taken together denote CH=CH-CH=CH-Z is pirimidine 4-il, piridine 4-il, piridine 2-il or phenyl R4, R5 independently from one another denote hydrogen, lower alkyl, trifluoromethyl, halogene, lower alcoxy, nitrilo, amino, lower alkyl amino, di-lower-alkylamino, piperazinyl, morfolinile; pirolidinile, vinyl, C3-C6-cycloalkyl, C3-C6 cycloalkenyl, terc-butiletinyl, hydroxyalkiletienile, naphtyl, tiophenyl or phenyl that can be substituted by halogene, lower alcoxy- lower alkyle, trifluorometile or nitro-group or denotes group -NH(CH2)nNR6R7, -N(CH3)(CH2)nNR6r7, -NH(CH2)n-morfolin-4-il ili -NH(CH2)n-OH, n-2-4 R6 and R7 independently from one another denote hydrogen or lower lakyl and their pharmaceutically acceptable salts. It has been found that the compounds of the formula I have selective affinity towards 5 HT-6 receptors. |
