发明名称 |
Ökning av antistoffbaserte fusjonsproteiners halveringstid i blodomlöpet |
摘要 |
Disclosed are compositions and methods for enhancing the circulating half-life of antibody-based fusion proteins. Disclosed methods and compositions rely on altering the amino acid sequence of the junction region between the antibody moiety and the fused protein moiety in an antibody-based fusion protein. An antibody-based fusion protein with an altered amino acid sequence in the junction region has a greater circulating half-life when administered to a mammal. Disclosed methods and compositions are particularly useful for reducing tumor size and metastasis in a mammal. |
申请公布号 |
NO20023774(D0) |
申请公布日期 |
2002.08.09 |
申请号 |
NO20020003774 |
申请日期 |
2002.08.09 |
申请人 |
MERCK PATENT GMBH |
发明人 |
GILLIES, STEPHEN D;BURGER, CHRISTA;LO, KIN-MING |
分类号 |
A61K39/44;A61K47/48;C07K5/103;C07K14/47;C07K14/52;C07K14/525;C07K14/55;C07K14/705;C07K16/00;C07K16/18;C07K16/30;C07K19/00;(IPC1-7):C07K |
主分类号 |
A61K39/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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