发明名称 |
REAGENTS AND METHODS FOR IDENTIFYING AND MODULATING EXPRESSION OF TUMOR SENESCENCE GENES |
摘要 |
This invention identifies tumor senescence genes induced by treatment with cytotoxic agents. The invention provides reagents and methods for identifyin g compounds that induce expression of these cellular genes and produce cellula r senescence, particularly senescence in tumor cells. The invention also provides reagents that are recombinant mammalian cells containing recombinan t expression constructs that express a reporter gene under the transcriptional control of a promoter for a gene the expression of which is modulated in senescent cells, and methods for using such cells to identify compounds that modulate expression of these cellular genes.
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申请公布号 |
CA2432976(A1) |
申请公布日期 |
2002.08.08 |
申请号 |
CA20012432976 |
申请日期 |
2001.12.21 |
申请人 |
BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
发明人 |
RONINSON, IGOR B.;CHANG, BEY-DIH |
分类号 |
C12Q1/68;G01N33/50;(IPC1-7):C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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