发明名称 |
Compositions and methods for inhibition of HIV-1 infection |
摘要 |
This invention provides a composition which comprises an admixture of three compounds, wherein: (a) one compound is an antibody which binds to a CCR5 receptor; (b) one compound retards attachment of HIV-1 to a CD4+ cell by retarding binding of HIV-1 gp120 envelope glycoprotein to CD4 on the surface of the CD4+ cell; and (c) one compound retards gp41 from adopting a conformation capable of mediating fusion of HIV-1 to a CD4+ cell by binding noncovalently to an epitope on a gp41 fusion intermediate; wherein the relative mass ratio of any two of the compounds in the admixture ranges from about 100:1 to about 1:100, the composition being effective to inhibit HIV-1 infection of the CD4+ cell. This invention also provides a method of inhibiting HIV-1 infection of a CD4+ cell which comprises contacting the CD4+ cell with an amount of the composition of the subject invention effective to inhibit HIV-1 infection of the CD4+ cell so as to thereby inhibit HIV-1 infection of the CD4+ cell.
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申请公布号 |
US2002106374(A1) |
申请公布日期 |
2002.08.08 |
申请号 |
US20010912824 |
申请日期 |
2001.07.25 |
申请人 |
OLSON WILLIAM C.;MADDON PAUL J. |
发明人 |
OLSON WILLIAM C.;MADDON PAUL J. |
分类号 |
A61K38/00;A61K38/16;A61K39/395;A61K45/06;A61P31/18;C07K14/16;C07K16/28;(IPC1-7):A61K39/42;C12N5/06;C12N5/16;C07K16/00;C12P21/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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