发明名称 GENETIC VACCINE THAT MIMICS NATURAL VIRAL INFECTION AND INDUCES LONG-LASTING IMMUNITY TO PATHOGENS
摘要 Genetic vaccines and methods are provided for enhancing the immunity of a host such as a human to one or more pathogens. In one embodiment, a recombinant benign virus is provided as the genetic vaccine. The recombinant virus comprises: an antigen sequence heterologous to the recombinant virus that encodes a viral antigen from a pathogenic virus, expression of the viral antigen eliciting an immune response directed against the viral antigen anD cells expressing the viral antigen in a host upon infection of the host by the recombinant virus; and an immuno-stimulator sequence heterologous to the recombinant virus that encodes an immuno-stimulator whose expression in the host enhances the immunogenicity of the viral antigen. The recombinant virus is replication-incompetent and does not cause a malignancy naturally associated with the pathogenic virus in the host. The genetic vaccines can be used for immunizing a host against a wide variety of pathogens, such as HIV, Ebola virus, hepatitis B virus, hepatitis C virus, influenza virus, pathogenic bacteria and parasites.
申请公布号 WO0191536(A3) 申请公布日期 2002.08.08
申请号 WO2001US18238 申请日期 2001.06.04
申请人 GENPHAR, INC.;WANG, DANHER 发明人 WANG, DANHER
分类号 C12N15/09;A61K39/00;A61K39/02;A61K39/12;A61K39/21;A61K39/235;A61K39/245;A61K39/29;A61P31/04;A61P31/12;A61P33/00;C07K14/08;C07K14/16;C12N7/00;C12N15/33;C12N15/83 主分类号 C12N15/09
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