发明名称 |
HIGH THROUGHPUT GENETIC SCREENING OF LIPID AND CHOLESTEROL PROCESSING USING FLUORESCENT COMPOUNDS |
摘要 |
The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism. The present invention is a mutant fish containing a metabolic defect affecting phospholipid and cholesterol processing. The mutant fish is useful for studying phospholipid and cholesterol metabolism and for screening compounds designed to treat disorders of phospholipid and/or cholesterol metabolism. |
申请公布号 |
WO02061073(A2) |
申请公布日期 |
2002.08.08 |
申请号 |
WO2002US02766 |
申请日期 |
2002.01.30 |
申请人 |
THOMAS JEFFERSON UNIVERSITY;FARBER, STEVEN;PACK, MICHAEL |
发明人 |
FARBER, STEVEN;PACK, MICHAEL |
分类号 |
C12N15/85;G01N33/50 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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