| 摘要 |
<p>The present invention relates to the function of a polypeptides named HP1122, Cj1464 and PA3351 which are the anti-σ28 factor of Helicobacter pylori, Campylobacter jejuni and Pseudomonas aeruginosa, respectively. The present invention also relates to a polypeptide named SID1122 which is the domain of Helicobacter pylori's HP1122 polypeptide involved in a specific interaction with Helicobacter pylori σ28 (HP1032) and which has an anti-σ28 factor activity. More specifically, the present invention relates to SID1122 polypeptide that interact with HP1032, identification of the HP1032 interacting domain (SID1032) that is specifically involved in the interaction with HP1122, complexes of two polypeptides such as HP1122 HP1032, or SID1122 SID1032, fragments and variants of the SID1122 and SID1032 polypeptides, antibodies to the SID1122 and SID1032 polypeptides, methods for screening drugs or agents which modulate the interaction of Helicobacter pylori's polypeptides encoded by HP1122 and HP1032 and pharmaceutical compositions for treating or preventing Gram negative flagellated bacteria infection in a human or mammal, more specifically Helicobacter sp. or Campylobacter jejuni or Pseudomonas aeruginosa infection, in particular Helicobacter pylori infection in a human or a mammal.</p> |
