发明名称 |
PYK2 PHOSPHORYLATION BY HER3 INDUCES TUMOR INVASION |
摘要 |
The present invention relates to the use of a HER2 protein or a nucleic acid coding therefor as a target for the modulation of the mitogen-activated protein (MAP) kinase pathway. Further, the use of a PYK2 protein and a nucleic acid coding therefor as a target for the modulation of the MAP kinase pathway is described. By inhibiting HER3 kinase activity, the phosphorylation of PYK2 and thus the stimulation of the MAP kinase pathway is inhibited. The present invention is preferably suitable for applications, particularly diagnostic or medical applications, wherein an inhibition of the MAP kinase pathway is desired. Thus, the invention relates to novel methods for diagnosing, treating or preventing MAP kinase associated disorders such as tumors.
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申请公布号 |
WO02060470(A1) |
申请公布日期 |
2002.08.08 |
申请号 |
WO2002EP01015 |
申请日期 |
2002.01.31 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.;ULLRICH, AXEL;VAN DER HORST, EDWARD, HTUN |
发明人 |
ULLRICH, AXEL;VAN DER HORST, EDWARD, HTUN |
分类号 |
A61K31/7052;A61K38/00;A61K38/17;A61K38/45;A61K39/395;A61P29/00;A61P35/00;A61P35/02;A61P43/00;C12Q1/48;G01N33/68;(IPC1-7):A61K38/17 |
主分类号 |
A61K31/7052 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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