发明名称 |
Preparation of cis-6-hexadecenoic acid, useful in cosmetic and dermatological applications, involves reacting triphenylphosphonium salt with aldehyde in Wittig reaction, and saponifying the resulting ester |
摘要 |
<p>Cis-6-hexadecenoic acid is prepared by reacting a triphenylphosphonium salt with decanal or other aldehyde in a Wittig reaction, and saponifying the resulting ester. Preparation of cis-6-hexadecenoic acid of formula COOH-(CH2)4-CH=CH-(CH2)8-CH3 involves: (a) reacting either: (i) a triphenylphosphonium salt of formula R1>OOC-(CH2)5-P(R2>)3+>X-> with decanal of formula CH3-(CH2)8-CH=O, or (ii) a triphenylphosphonium salt of formula CH3-(CH2)9-P(R2>)3+>X-> with an aldehyde of formula R1>OOC-(CH2)4-CH=O in a Wittig reaction; and (b) saponifying the resulting ester of formula R1>OOC-(CH2)4-CH=CH-(CH2)8-CH3. R1>1-12C alkyl or aryl; R2>aryl; X->anion equivalent of (in)organic acid.</p> |
申请公布号 |
DE10105799(A1) |
申请公布日期 |
2002.08.08 |
申请号 |
DE2001105799 |
申请日期 |
2001.02.07 |
申请人 |
BASF AG |
发明人 |
KLEIN, DANIELA;ERNST, HANSGEORG;KOPPENHOEFER, JUERGEN |
分类号 |
C07C51/09;C07C67/343;(IPC1-7):C07C51/09;C07C51/353;C07C57/03 |
主分类号 |
C07C51/09 |
代理机构 |
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地址 |
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