Analogues of lipopolysaccharide-binding protein (LBP)-derived peptides that efficiently neutralize lipopolysaccharides (LPS)

摘要

The present invention is for a pharmaceutical composition comprising an effective amount of an lipopolysaccharide (LPS) binding and -neutralizing peptide. The LPS binding and neutralizing peptides of the present invention are analogues of peptides from a lipopolysaccharide binding protein region whose primary sequence have been substituted at particular amino acid sites to obtain an effective binding to and neutralization of LPS.