| 发明名称 |
Modified forms of hepatitis C NS3 protease for facilitating inhibitor screening and structural studies of protease:inhibitor complexes |
| 摘要 |
The present invention relates to modified Hepatitis C NS3 proteases and modified Hepatitis C NS4a-NS3 fusion proteases. These proteins are highly soluble and are useful for NMR spectroscopy, X-ray crystallography, and inhibitor screening. DNA constructs are also provided.
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| 申请公布号 |
US2002106642(A1) |
申请公布日期 |
2002.08.08 |
| 申请号 |
US20010965594 |
申请日期 |
2001.09.27 |
| 申请人 |
WITTEKIND MICHAEL;WEINHEIRNER STEVEN;ZHANG YAGUN;GOLDFARB VALENTINA |
发明人 |
WITTEKIND MICHAEL;WEINHEIRNER STEVEN;ZHANG YAGUN;GOLDFARB VALENTINA |
| 分类号 |
C12N15/09;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/50;C12R1/19;(IPC1-7):C12Q1/70 |
主分类号 |
C12N15/09 |
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