发明名称 |
USE OF 9-SUBSTITUTED HYPOXANTHINE DERIVATIVES TO STIMULATE REGENERATION OF NERVOUS TISSUE |
摘要 |
The present invention comprises a method of stimulating regeneration or survival of a mammalian motor neuron or of a mammalian sensory neuron comprising administering to a mammal an effective amount of a compound that is a 9-substituted hypoxanthine derivative linked through a linker to p-aminobenzoic acid moiety or of a salt or prodrug ester of such a compound. Preferably, the compound is N-4-carboxyphenyl-3-(6-oxohydropurin-9-yl) propanamide. The invention also includes pharmaceutical compositions formulated for stimulation of regeneration of a mammalian motor neuron comprising the 9-substituted hypoxanthine derivative and a pharmaceutically acceptable carrier.
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申请公布号 |
WO0136419(A9) |
申请公布日期 |
2002.08.08 |
申请号 |
WO2000US41645 |
申请日期 |
2000.10.27 |
申请人 |
NEOTHERAPEUTICS, INC.;GLASKY, ALVIN |
发明人 |
GLASKY, ALVIN |
分类号 |
A61K31/522;A61K38/22;A61P21/06;A61P25/00;A61P25/16;A61P25/28;A61P31/18;A61P37/00;A61P43/00;C07D473/30;(IPC1-7):C07D473/30 |
主分类号 |
A61K31/522 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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