| 摘要 |
<p>A method for preparing a therapeutic aqueous disodium pamidronate solution comprising: (a) preparing a slurry of pamidronic acid in water, and (b) combining aqueous sodium hydroxide with said slurry in an about 2:1 molar ratio of sodium hydroxide to pamidronic acid; to yield a solution of disodium pamidronate having visual clarity and a pH of about 6.5; (c) packaging at least one liquid unit dosage of said solution in a sealed ampule or vial.</p> |
