ALKOXYIMINOALKANOIC ACID DERIVATIVES

摘要

A compound represented by the formula wherein R<1> is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond, an oxygen atom, a sulfur atom, or a group represented by -CO-, -CS-, -CR<6))- or -NR<8>- (R<6> and R<8> are each a hydrogen atom or an optionally substituted hydrocarbon group, and R<7> is a hydrogen atom or a hydroxy-protecting group); n is an integer of 0 to 3; Y is an oxygen atom, a sulfur atom, or a group represented by -SO-, -SO2-, -NR<8>-, -CONR<8>- or -NR<8>CO- (R<8> is a hydrogen atom or an optionally substituted hydrocarbon group); ring A is a heterocycle optionally having 1 to 3 additional substituents or a hydrocarbon ring optionally having 1 to 3 additional substituents; p is an integer of 1 to 8; R<2> is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; q is an integer of 0 to 6; m is 0 or 1; R<3> is a group represented by -OR<9> (R<9> is a hydrogen, atom or an optionally substituted hydrocarbon group) or -NR<10>R<11> (R<10> and R<11> are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, or an optionally substituted acyl group, and R<10> and R<11> may be taken together to form a ring); R<4> and R<5> are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R<4> and R<2> may be taken together to form a ring, provided that, when ring A is an optionally substituted indole, Y is not an oxygen atom or a sulfur atom; when Y is an oxygen atom, a sulfur atom, -SO-, -SO2- or -NR<8>- (R<8> is as defined above), ring A is not a benzene ring optionally having substituents; and when Y is an oxygen atom and ring A is an optionally substituted . 4-pyrone, an optionally substituted 4-pyridone or an optionally substituted pyridine-N-oxide, R<2> is not a thiazole substituted by an optionally protected amino group or a thiadiazole substituted by an optionally protected amino group, and a salt thereof are useful as an agent for the prophylaxis or treatment of diabetes and the like.