发明名称 |
PEPTIDE RADIOPHARMACEUTICAL APPLICATIONS |
摘要 |
The invention relates to radiotherapy with somatostatin-derived peptides labeled with medically useful metal ions. The invention in particular provides for methods and reagents for labeling somatostatin-derived peptides with perrhenate, in which a solution including somatostatin-derived peptide analogue containing at least one disulfide bond is provided, the solution is reacted with stannous ions and with a radioisotope, wherein the stannous ions are sufficient to substantially reduce the disulfide bonds of the peptide and the radioisotope, and the radiolabeled somatostatin-derived peptide analogue recovered. Also provided are methods for regional administration of radiolabeled somatostatin-derived peptides, methods for enhanced regional retention of radiolabeled somatostatin-derived peptides, methods for treatment of arthritis using radiolabeled somatostatin derived peptides, and methods for stabilizing radiolabeled somatostatin derived peptides. |
申请公布号 |
EP0827412(A4) |
申请公布日期 |
2002.08.07 |
申请号 |
EP19960916556 |
申请日期 |
1996.05.22 |
申请人 |
RHOMED INCORPORATED |
发明人 |
ZAMORA, PAUL, O.;RHODES, BUCK, A.;MAREK, MICHAEL, J. |
分类号 |
A61K9/00;A61K38/00;A61K49/08;A61K51/00;A61K51/08;A61K51/10;A61P29/00;A61P35/00;C07K5/083;C07K7/06;C07K7/64;C07K14/00;C07K14/52;C07K14/655;C07K14/78;(IPC1-7):A61K51/00;A61M36/14 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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