m-SUBSTITUTED BENZOIC ACID DERIVATIVES EXHIBITING INTEGRIN ALPHA-V BETA-3 ANTAGONISM

摘要

An object of the present invention is to provide m-substituted benzoic acid derivatives having integrin alpha v beta 3 antagonistic activity. The derivatives according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof, which are useful for the treatment or prevention of cardiovascular diseases, angiogenesis-related diseases, cerebrovascular diseases, cancers and metastasis thereof, immunological diseases, osteopathy and other diseases: <CHEM> wherein A represents an optionally substituted heterocyclic group containing two nitrogen atoms, a bicylic group or the like; D represents a bond, >NR<4>, >CR<5>R<6>, O, S, or -NR<4>-CR<5>R<6>-; X represents CH or N; R<7> and R<8> represent hydroxyl, alkyl or the like; Q represents >C=O or the like; R<9> represents hydrogen, alkyl or the like; J represents a bond or alkylene; R<10> represents optionally substituted hydroxyl, amino or the like; R<11> represents hydrogen, alkyl or the like; m is 0 to 5; n is 0 to 4; and p and q are each 0 to 3.