| 摘要 |
<p>Substituted fused heterocyclic compounds represented by general formula (I) or pharmacologically acceptable salts thereof, excellent in the effects of ameliorating insulin resistance, inhibiting 5-lipoxygenase, and suppressing lipid peroxide formation wherein R1 represents general formula (II) wherein R4 represents substituted phenyl or optionally substituted pyridyl; R5 represents hydrogen, etc.; R6 represents hydrogen, C1-C6 alkyl, etc.; D represents oxygen or sulfur; and E represents a group bearing CH or nitrogen; R2 represents hydrogen, etc.; R3 represents 2, 4-dioxothiazolidin-5-ylmethyl, etc.; A represents C1-C6 alkylene; and B represents oxygen or sulfur.</p> |
