COMPOUNDS NAMED THE ADENOPHOSTINS, THEIR PREPARATION AND THEIR THERAPEUTIC USE

摘要

Compounds of formula (I): (wherein R represents a hydrogen atom or an acetyl group); which eve have named "the adenophostins", and salts and esters thereof, have the ability to increase intracellular calcium ion concentrations by acting on the inositol 1,4,5-trisphosphate (InsP3) receptors which exist in the endoplasmic reticulum, and can therefore be used fox the treatment or prophylaxis of cerebral disorders. They can be prepared by cultivation of a microorganism of the genus Penicillium, e.g. Penicillium brevicompactum SANK 11991 (FERM BP-3499) or Penicillium brevicompactum SANK 12177 (FERM BP-3500).