发明名称 |
Immunoregulatory molecules for costimulatory signal transduction |
摘要 |
An immunoregulatory molecule that regulates costimulatory signal transduction through interaction with the molecules involved in costimulatory signal transduction present on antigen presenting cells and/or T cells in the activation of T cells by antigen presenting cells and a process for preparing the same are provided. Said immunoregulatory molecule comprises a peptide which has two cysteine (Cys) residues forming Cys-Cys linkage and comprises at least six amino acid residues between said Cys-Cys linkage. Said immunoregulatory molecule is obtained by screening a phage random peptide library with a monoclonal antibody to CTLA-4 on T cells involved in costimulatory signal transduction.
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申请公布号 |
US6429286(B1) |
申请公布日期 |
2002.08.06 |
申请号 |
US19990403089 |
申请日期 |
1999.10.15 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
SUGIMURA KAZUHISA |
分类号 |
C07K14/47;C07K14/725;C07K16/28;G01N33/50;(IPC1-7):C07K7/08;C07K7/64;A61K38/10;A61K38/12 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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