发明名称 |
CELL CHEMOTACTIC FACTOR (CCTF) ORIGINATING IN MAMMALIAN TOOTH PRICEMENT OR CEMENT, METHOD FOR PURIFYING THE SAME, AND NOVEL CONNECTIVE TISSUE ADHESION PROMOTERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT |
摘要 |
A precementum- and/or cementum-derived chemotactic factor (CCTF) of a tooth of a Mammalian is characterized by a molecular weight measured by SDS-PAGE of 67000±1000. A process for purifying a precementum- and/or cementum-derived gingival fibroblast chemotactic factor (CCTF) of a Mammalian tooth includes eluting a protein mixture from precementum and/or cementum of a Mammalian tooth and purifying the precementum- and/or cementum-derived chemotactic factor (CCTF) from the eluted protein mixture by molecular weight fractionation, ion-exchange adsorption chromatography and hydroxyapatite adsorption chromatography. In the process for purifying the gingival fibroblast chemotactic factor (CCTF) the Mammalian is preferably a bovine.
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申请公布号 |
US6429193(B1) |
申请公布日期 |
2002.08.06 |
申请号 |
US20000486020 |
申请日期 |
2000.02.18 |
申请人 |
KANEBO, LTD. |
发明人 |
MUNEKATA MASANOBU;NISHIMURA KAZUAKI |
分类号 |
A61K38/00;C07K14/52;(IPC1-7):A62K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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