| 摘要 |
The present invention discloses compound of formula (I) or any of its enantiomers or any mixture thereof, a pharmaceutically acceptable addition salt thereof or the N-oxide thereof wherein X and Y together form =O, =S, =NOR2, =CR3R4, =N-CN, =N-NR7R8, -(CH2)m-, or -W'-(CH2)p-W"-, or one of X and Y is hydrogen and the other is -OR5, -SR5, or -NR5R6, Z is hydrogen, -COOR9; R 3 and R4 are independently hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alcoxy, aryl, arylalkyl, or -(CH2)q-COOR2 ; R2, R5 and R6 are independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl , alkenyl, alkynyl, aryl, or arylalkyl, -CO-alkyl, or -SO2-alkyl; R7 and R8 ar e independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl , aryl or arylalkyl; R9 is alkyl, alkenyl or alkynyl; R1 is alkyl, alkenyl, alkynyl, aryl, or arylalkyl; where said aryl groups may be substituted one o r more times with substituents selected from the group consisting of halogen, CF3, CN, alkoxy, cycloalkoxy, alkyl, cycloalkyl, alkenyl, alkynyl, amino and nitro; W' and W" are each independently O or S; n is 1, 2, 3 or 4; m is 2, 3 , 4 or 5; p is 1, 2, 3, 4, or 5; and q is 0, 1, 2, 3, or 4. The compounds possess valuable properties as monoamine neurotransmitter, i.e dopamine, and serotonine, reuptake inhibitors.
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