| 摘要 |
<p>Diagnostic compsns. contg. one or more complex salts (I) dissolved or suspended in an H2O-contg. medium are new, where (I) are salts of the anion of a complex-forming acid and one or more central ions of elements with atomic nos. of 21-29, 42, 44 or 57-83 and opt. one or more cations of inorganic and/or organic bases or amino acids. Complex salts of formula (Ia) are new (where X is COOY, PO3HY or CONHOY; A is CHR2CHR3, CH2CH2(ZCH2CH2)m, CH2CH(N(CH2X)2)CH2 or CH2CH2N(CH2CH2N(CH2X)2)CH2CH2; R1 is H or Me; R2 and R3 are H, lower alkyl, phenyl or benzyl, or R2+R3 is (CH2)3 or (CH2)4, or R2 is H and R3 is (CH2)p-C6H4-W-protein; p= 0 or 1; W is NH, NHCOCH2 or NHCS; m= 1-3; Z is O, S, NCH2X or NCH2CH2OR4; R4 is lower alkyl; V is as defined for X or is CH2OH, CONH(CH2)nX or COB, or V+V is (CH2)wN(CH2X)CH2CH2N(CH2X)(CH2)w when R1= R2= R3= H; B is a protein or lipid residue; n= 1-12; w= 1-3; with the proviso that there are 3-12 Y substituents, at least 2 being an equiv. of an ion of a metal with an atomic no. of 21-29, 32, 3 44 or 57-83 and at least one being a cation of an organic base or amino acid, any others being H or cations of an inorganic base). The compsns. may be used as NMR contrast agents for nuclear spin tomography, as X-ray contrast agents for radiography or as ultrasonic diagnostic agents.</p> |
