IN VITRO ASSAY FOR TESTING GABAPENTINOID ACTIVITY

摘要

An assay and method for selecting analogs and derivatives of gabapentin based on the compounds inhibitory activity toward MAP kinase and MAP kinase mediated reporter gene expression. The method includes the steps of activati ng the MAP kinase signaling pathway, detecting the MAP kinase signal, and screeni ng the gabapentin analogs and derivatives for inhibitory activity against the M AP kinase signal.