发明名称 |
Variants of thymidine kinase, related nucleic acids sequences and their use in genic therapy |
摘要 |
The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their use in genic therapy.
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申请公布号 |
US2002102247(A1) |
申请公布日期 |
2002.08.01 |
申请号 |
US20000734357 |
申请日期 |
2000.12.12 |
申请人 |
CROUZET JOEL;BLANCHE FRANCIS;COUDER MICHEL;CAMERON BEATRICE |
发明人 |
CROUZET JOEL;BLANCHE FRANCIS;COUDER MICHEL;CAMERON BEATRICE |
分类号 |
C12N15/09;A61K31/00;A61K31/70;A61K31/7088;A61K31/711;A61K38/00;A61K48/00;A61P35/00;C12N9/12;C12N15/38;(IPC1-7):A61K38/52;C07H21/04;C12P21/02;C12N5/06 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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