发明名称 |
Method for reducing or preventing the establishment, growth or metastasis of cancer by administering indole peptidomimetics PAR-1 antagonist and optionally PAR-2 antagonists |
摘要 |
We have discovered a method of modifying the tumor cell microenvironment to reduce or prevent the establishment, growth or metastasis of malignant cells comprising administering to a patient having malignant cells a pharmaceutically effective amount of a PAR-1 inhibitor and optionally a PAR-2 inhibitor to prevent or reduce activation of normal cells within the tumor microenvironment. This method also has the effect in some patients of modulating the immune system to facilitate a more efficient immune response to malignant cells and maybe coupled with cytokine therapy and T-cell therapy to enhance the patient's immune response to the malignant cells.
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申请公布号 |
US2002103138(A1) |
申请公布日期 |
2002.08.01 |
申请号 |
US20010865824 |
申请日期 |
2001.05.25 |
申请人 |
D'ANDREA MICHAEL;DERIAN CLAUDIA;WOODROW HAL BRENT |
发明人 |
D'ANDREA MICHAEL;DERIAN CLAUDIA;WOODROW HAL BRENT |
分类号 |
A61K38/00;C07K5/065;C07K5/078;(IPC1-7):A61K38/05;C0743/02;C07D209/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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