PROCESS FOR PREPARATION OF CYANOPHENYLBENZOIC ACID DERIVATIVES

摘要

A process for preparation of compounds represented by the general formula (IV) or salts thereof which comprises condensing a compound of the general formula (I) with 4-(aminomethyl)- piperidine through dehydration to obtain a compound of the general formula (II), protecting the piperidine secondary amine of the compound (II) to thereby obtain a compound of the general formula (III), and reducing the imine moiety of the compound (III) (in the formulae, each wavy line means that the double bond has an E- or Z-configuration or a mixture of both; R is hydrogen, C1-8 alkyl, or the like; and R' is C1-8 alkylcarbonyl, arylcalbonyl, or the like). (II) (III) (IV)