INTERMEDIATE COMPOUNDS USEFUL FOR MAKING ANTIVIRAL COMPOUNDS

摘要

Novel compounds of Formula I and Formula II (below): formula (I) wherein Ra is selected from the group consisting of -CH2-OCH3, -CH2-OCH2CH3, -CH(CH3)OCH2CH3, -CH2-OCH2CH2-OCH3, -CH2OCH2CH2-Si(CH3)3, and formula (II); R1 is a radical selected from the group consisting of hydrogen, halogen, perfluoroalkyl, nitro, carbalkoxy, carboxamide, carboxamidoalkyl, alkyl, cycloalkyl, alkoxy, alkoxyalkyl, alkoxy-C2-C6-alkoxy, alkylsulfinyl, alkylsulfonyl, sulfonamide, cyano, amido, dialkylamino, ORa, or a heterocyclic radical selected from the group consisting of morpholinyl, piperadinyl, pyrrolidinyl, or an N-substituted piperazinyl, said piperazinyl substituents selected from an alkyl group, the point of attachment of said heterocyclic radical is at a nitrogen atom; P is a protected formaldehyde group such as: formula (III) or formula (IV) wherein R2, R3, R4 and R5 are independently selected from the group consisting of hydrogen or alkyl. The compounds are useful for making antiviral agents.