QUANTITATIVE ASSESSMENT OF ERBB/HER RECEPTORS IN BIOLOGICAL FLUIDS

摘要

This invention provides a method for determining the amount of a protein which selectively binds to a transmembrane isoform of a neuregulin protein and induces nuclear translocation of the isoform, in a biological sample. The invention also provides methods for detecting other functional molecules, methods for treating diseases, including neurodegenerative diseases and cancer, compounds and pharmaceutical compositions, and cells used in the methods describes herein.