| 摘要 |
<p>In the present invention is disclosed the use of artificial chromosomes for the coordinated and controllable expression of large numbers of heterologous genes in a single host cell. In particular, the invention relates to an artificial chromosome comprising at least two co-ordinatedly expressible nucleotide sequences, an artificial chromosome comprising at least two expression cassettes and a host cell comprising at least one of these artificial chromosomes as well as to a host cell comprising at least three different artificial chromosomes.</p> |
