A gene and a protein widely relating to cancer infiltration, kidney diseases, lung diseases, etc. and a method of efficiently evaluating a substance controlling the activity of this protein. DNA having a base sequence represented by SEQ ID NO:1 or 2; a serine protease encoded by the DNA; a method of evaluating a compound controlling the activity of the above protein by using an antisense nucleic acid against the DNA sequence as described above, the above protein or a partial model structure thereof; an antisense nucleic acid against the DNA; and an antibody specific to the above protein.
