| 摘要 |
A method for reducing the incidence or delaying the onset of diabetes in diabetes-susceptible mammals (e.g., mice, rats, humans) is provided wherein the mammals are treated with a gonadotropin-releasing hormone (GnRH) antagonist. Preferably, the antagonist is administered repeatedly over time by subcutaneous injection. A useful antagonist is Acetyl-β-[2-Napthyl]-D-Ala-D-p-Chloro-Phe-β[3-Pyridyl]-D-Ala-Ser-Nε-[Nicotinoyl]-Lys-Nε[Nicotinoyl]-D-Lys-Leu-Nε-[Isopropyl]-Lys-Pro-D-Ala-NH2. Other useful antagonists are Nal-Glu, PPI-149 and acryline.
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