发明名称 |
PROCESSES AND SYNTHETIC INTERMEDIATES FOR PREPARING N-ARYLACRIDANCARBOXYLIC ACID DERIVATIVES |
摘要 |
Synthetic processes and intermediates are disclosed for the preparation of N-arylacridancarboxylic acid derivatives. The derivatives are esters, thioesters, amides and sulfonimides. A key feature of the processes is the preparation of N-aryl substituted intermendiates by formation of a bond between the nitrogen atom of the acridan ring and a carbon atom of another aromatic or heteroaromatic ring compound. The arylation reaction is catalyzed by a palladium catalyst. The N-arylacridan-carboxylic acid derivatives are useful in methods for producing light and in assays for peroxidase enzymes and enzyme inhibitors and in assays employing enzyme-labeled specific binding pairs.
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申请公布号 |
WO02059096(A1) |
申请公布日期 |
2002.08.01 |
申请号 |
WO2001US44700 |
申请日期 |
2001.12.07 |
申请人 |
LUMIGEN, INC. |
发明人 |
AKHAVAN-TAFTI, HASHEM;EICKHOLT, ROBERT, A.;HANDLEY, RICHARD, S. |
分类号 |
C07B61/00;C07D219/02;C07D219/04;C07D219/06;C07D219/08;C07D401/04;C07D417/04;(IPC1-7):C07D221/06 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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