ACYLATION OF AMINO-ISOTHIAZOLES USING TRIALKY-ALUMINIUM AGENTS

摘要

Method for preparing a compound (I): from the corresponding isothiazole amine and for example an ester, using a trialkyl-aluminium compound R<50>R<51>R<52>AI where R<50>, R<51> and R<52> are each independently C1-10 alkyl. The method is particularly suitable for use when the ester is base- and/or nucleophile-sensitive, especially when R<7> is an electron withdrawing group. Also provided is a trialkyl-aluminium intermediate compound formed during the method.