发明名称 |
SPECIFIC HUMAN ANTIBODIES FOR SELECTIVE CANCER THERAPY |
摘要 |
The present invention is directed to a peptide or polypeptide comprising an Fv molecule, a construct thereof, a fragment of either, or a construct of a fragment having enhanced binding characteristics so as to bind selectively and/or specifically to a target cell in favor of other cells, wherein the binding selectivity or specificity is primarily determined by a first hypervariable region, and wherein the Fv is a scFv or a dsFv, and optionally having one or more tags. The enhanced binding is directed to a substantially exposed and/or over-expressed binding site on or in a target comprising a cell in favor of other cells on or in which the binding site is not substantially available and/or expressed. The invention is further directed to a method for isolating such peptides and polypeptides from a phage display library and to the nucleic acid molecules encoding them. The invention provides for a pharmaceutical composition comprising the peptide or polypeptide and kits for diagnosis and treatment of disease, specifically cancer, most specifically acute myeloid leukemia.
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申请公布号 |
CA2433227(A1) |
申请公布日期 |
2002.08.01 |
申请号 |
CA20012433227 |
申请日期 |
2001.12.31 |
申请人 |
BIO-TECHNOLOGY GENERAL CORP. |
发明人 |
SZANTON, ESTHER;LIPSCHITZ, ORLY;LAZAROVITS, JANETTE;GUY, RACHEL;HAGAI, YOCHEVED;PERETZ, TUVIA;PLAKSIN, DANIEL;LEVANON, AVIGDOR |
分类号 |
C12N15/09;A61K38/00;A61K38/02;A61K39/395;A61K51/00;A61P35/00;C07K14/47;C07K16/18;C12N15/13;C12P21/02;C12P21/08;C12Q1/02;C12Q1/68;(IPC1-7):C12N15/13;C07K7/04;G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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