Diagnostic kit for prenatal detection of trisomy 13, comprises primer pairs specific for amplification of short tandem repeat regions in chromosome 13

摘要

Diagnostic kit for detecting trisomy 13 in a human fetus comprises at least two pairs of oligonucleotide primers suitable for amplification, by polymerase chain reaction (PCR), of both strands of a target DNA sequence, i.e. a short tandem repeat region (X) of human chromosome 13. Independent claims are also included for the following: (1) microarray for detecting trisomy 13, especially a DNA chip, comprising an array of many separate fields, at least one of which carries an oligonucleotide able to hybridize to DNA that is part of X; and (2) method for detecting trisomy 13.