| 摘要 |
Disclosed herein are systemic formulations comprising beta-carotene and derivatives thereof and a solubilizer selected from tetrahydrofuran (THF), polyethylene glycol (PEG), and mixtures thereof. Generally, the formulations are administered to animals in need thereof in therapeutically effective amounts of beta-carotene and derivatives thereof for the purpose intended. T he solubilizers greatly enhance the bioavailability of beta-carotene administer ed systemically. Another embodiment of the present invention is a method for administering beta-carotene and derivatives thereof to an animal in need thereof by administering the formulation of the present invention. Yet anoth er embodiment is a method for treating an animal in need thereof by administeri ng a therapeutically effective amount of the formulation of the present invention. The invention includes a method for treating an animal suffering from or susceptible to sepsis by administering an effective amount for treating sepsis of the formulation of the present invention.
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