| 摘要 |
PROBLEM TO BE SOLVED: To obtain a safe fibrinolytic protease inhibitor capable of exhibiting excellent amleiorating and preventing effects on various kinds of skin diseases accompanying a change in activity of a fibrinolytic protease in the epidermis or skin conditions in which an epidermal proliferative abnormality such as skin roughening or common acne caused by irritation by drying, a detergent, etc., is recognized. SOLUTION: This fibrinolytic protease inhibitor comprises one or more kinds selected from an amide derivative of tranexamic acid represented by the following general formula (1) wherein, R1 and R2 denote each hydrogen atom, a 1-18C linear or branched alkyl group, a 5-8C cycloalkyl group, benzyl group and/or the following general formula (2) [wherein, X denotes a lower alkyl group, a lower alkoxy group, hydroxy group, amino group or a halogen atom; and n is 0-3]; and R1 and R2 may each be the same or different}.
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