| 摘要 |
PURPOSE:To obtain a new imidazolidinetrione derivative useful as an intermediate for producing an extremely useful therapeutic agent for peptic ulcer. CONSTITUTION:A compound of formula I (R<1> is 1-6C alkyl; A is ethylene, propylene, butylene or butenylene), e.g. 1-ethyl-3-[3-(3-folmylphenoxy) propyl]imidazolidinetrione. The compound is obtained by reacting a compound of formula II (X is halogen) with m-hydroxybenzaldehyde of formula III in the presence of a basic catalyst. The compound of formula II is a new compound and obtained by reacting a compound of formula IV with oxalic acid chloride. The compound of formula I is reacted with piperidine to provide a compound of formula V useful as a therapeutic agent for peptic ulcer. |
