发明名称 4-(1H-PYRROL-1-YL)IMIDAZOLES WITH ANGIOTENSIN II ANTAGONIST ACTIVITY
摘要 Substituted 4-(1-H-pyrrol-1-yl)imidazoles of formula (I) are disclosed as we ll as methods of preparing them, pharmaceuti- cal compositions containing them, and methods of using them. Novel intermediates useful in the preparation of the compounds of the invention are also disclosed and synthetic methods for preparing the novel intermediates. The compounds are useful as an- tagonists of angiotensin II and thus are useful in the control of hypertension, hyperaldosteronism, congestive heart failure, glau- coma, vascular smooth muscle proliferation associated with atherosclerosis, and with postsurgical vascular restenosis.
申请公布号 CA2110806(C) 申请公布日期 2002.07.30
申请号 CA19922110806 申请日期 1992.05.28
申请人 WARNER-LAMBERT COMPANY 发明人 HODGES, JOHN COOKE;TOPLISS, JOHN GORDON
分类号 A61K31/415;A61K31/4178;A61P9/00;A61P9/10;A61P9/12;A61P27/02;C07D233/54;C07D233/90;C07D403/04;C07D403/14;(IPC1-7):C07D403/04 主分类号 A61K31/415
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