发明名称
摘要 <p>A method of substituting fluorine for the or each chlorine atom in a compound of the formula: R<1>R<2>X<1>C-O-CX<2>X<3>H in which formula: (a) X<1>,X<2> and X<3> are each independently selected from hydrogen, chlorine and fluorine atoms; (b) at least one of X<1>,X<2> and X<3> is a chlorine atom; (c) R<1> and R<2> are independently selected from an hydrogen atom; a halogenated methyl group, and a halogenated ethyl group; (d) at least one of R<1> and R<2> is a halogenated methyl group or a halogenated ethyl group wherein sodium fluoride or potassium fluoride is reacted with said compound at a temperature and an elevated pressure in the absence of added solvent.</p>
申请公布号 JPH0615485(B2) 申请公布日期 1994.03.02
申请号 JP19890113532 申请日期 1989.05.02
申请人 BOC GROUP INC 发明人 DONARUDO EFU HARUPAAN;MAAKU ERU ROBIN
分类号 A61K31/08;A61P23/00;C07C41/00;C07C41/22;C07C43/12;C07C67/00;(IPC1-7):C07C43/12 主分类号 A61K31/08
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