Fremgangsmåte og anordning for manipulering av magnetiske partikler, spesielt for blanding, separasjon, oppsamling ogvasking

摘要

A method and device is provided for the efficient mixing, separation, collection and washing of magnetic particles from fluids. The fluid in a suitable container containing the target entities and magnetic particles having an affinity for the said target entities is placed in a device of the present invention in a removable manner and the efficient mixing is effected additionally to a magnetic field collection system. Magnetic particles in small volumes can be washed and concentrated. Procedures for the further manipulation and detection of the target entities bound to the magnetic particles or the residual fluid are described. Depending on the embodiment employed, the device can be applied to a range of volumes from less than 100 µl to in excess of 100 ml.