TRANSFERRIN-POLYCATION/DNA COMPLEXES FOR THE SYSTEMIC TREATMENT OF TUMOUR DISEASES USING CYTOTOXIC PROTEINS
摘要
The invention relates to a DNA complex containing at least one DNA molecule and coding for at least one therapeutically effective protein having cytotoxic activity; and a transferrin-conjugated polycation, the zeta potential thereof being </= +15mV. The complex, in which a high proportion of transferrin shields the positive charge, enables therapeutic DNA to be transported to tumours in a targeted manner during the systemic treatment of tumour diseases.
申请公布号
WO0228439(A3)
申请公布日期
2002.07.25
申请号
WO2001EP11373
申请日期
2001.10.02
申请人
BOEHRINGER INGELHEIM INTERNATIONAL GMBH;KIRCHEIS, RALF;WAGNER, ERNST;WIGHTMAN, LIONEL;OSTERMANN, ELINBORG
