| 发明名称 |
BIFUNCTIONAL FUSION PROTEINS WITH GLUCOCEREBROSIDASE ACTIVITY |
| 摘要 |
The present invention relates to novel Glucocerebrosidase bifunctional fusio n proteins consisting essentially of an Immunoglobulin (Ig) molecule and a protein having the biological activity of Glucocerebrosidase, for enzyme replacement therapy and/or augmentation of glycolipid metabolism by the administration of bifunctional fusion proteins using a therapy based on the treatment of glycolipid storage disorders such as Gaucher's, Fabry's and Tay - Sachs diseases. |
| 申请公布号 |
CA2435037(A1) |
申请公布日期 |
2002.07.25 |
| 申请号 |
CA20012435037 |
申请日期 |
2001.12.27 |
| 申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG |
发明人 |
GILLIES, STEPHEN;SCHUMACHER, SILKE |
| 分类号 |
C12N15/09;A61K38/00;A61K38/47;A61P3/06;A61P3/10;C07K14/47;C07K16/00;C07K16/18;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/24;C12N15/56;C12N15/62 |
主分类号 |
C12N15/09 |
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